This open access book offers a groundbreaking examination of the profound and lasting impacts of COVID-19 on U.S.-China relations. It covers areas such as public health, trade and supply chain challenges, people-to-people connections, shifts in public opinion, rising nationalism, anti-Asian sentiments, and strategic assessments. Since the pandemic's outbreak in late 2019, China and the United States have both suffered catastrophically. So too has the U.S.-China relationship, which was already at a historic low point before COVID-19 accelerated its deterioration. With contributions by leading and emerging scholars from both nations, the volume reflects a collaborative effort, emphasizing the importance of bilateral dialogue. As the world steps into the post-COVID era, this work offers timely insights into the potential pathways for rebuilding and redefining U.S.-China relations.